• Mon. Sep 27th, 2021

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    Serum institute of India

     God sent on horseback warriors to chase Covid;  Cyrus Punewala and son Adar Punewala.  The hoof of a horse that started half a century ago is frozen.  It is also the history of one of the largest vaccine companies in the world. 

    When you hear the name Serum Institute of India, it seems that it is a government institution.  But Dr.  Cyrus Punewala (79) and his son Adar Punewala (40) run this family business at home and abroad.  Yesterday was Adar’s 40th birthday.  So it turned out to be an invaluable birthday present for the country. 

    For the first time in the history of the world, the dream of a vaccine came true so quickly with the success of the 4,000 Serum Institute staff, researchers and the Punewala family.  And Punewala has become a medicine of hope for mankind.

     A triumphal arch from the stables

     The Punewala family started a horse race that raises and trains racehorses.  In addition, horse sap was used to make antidotes for tetanus.  This is how one thinks of starting a system of bottling the sap on its own.  Such a business venture was a challenge in the early seventies.

     But the company, which started borrowing Rs 5 lakh with its brother Cyrus, is now a Rs 60,000 crore business empire.  Serum, which began production in 1974, including the DTP vaccine and antidote, became the largest company in the country in the 1990s.  He then became a participant in the World Health Organization’s vaccine programs.  Continuing growth only.  Today, the world calls Punewala a billionaire – God’s own drug dealer.

     The largest stable

     With the pride of about 300 racehorses, this largest stable in the country still thrives on the Serum campus.  ‘Vaccines should not cost more than a cup of tea.  Medicine should be affordable to the poor.  The philanthropist Punewala claims that at least 30 million children in the world have been saved.

     Punewala, a philanthropist and a classmate of Sharad Pawar, has set aside 60,000 doscovshields to give to Parsis around the world.

     Millions of doses of vaccine are stored in serum godowns at minus 20 degrees Fahrenheit.  ‘Wherever there is an epidemic in the world, the first investigation reaches the serum.  Serum will be able to deliver the medicine anywhere within 10 days, ”Punewala explained in an e-mail conversation.

     The annual production capacity of the Serum Institute of Life Sciences is about 150 million doses.  It is planned to have a production capacity of Rs 100 crore.  The serum-producing vaccine is available in 170 countries.  It is estimated that 70 percent of children in the world have used a serum vaccine at least once in their lives.  The Serum Research Center is the largest campus in India.  Junior Punewala’s new office is a redesigned Airbus A320 aircraft.

     Drug study at Oxford since January

     At the time of Covid’s research, the University of Oxford was under the leadership of Sarah Gilbert and Adrian Hill, professors at the Jenner Institute and the Oxford Vaccine Group.  Oxford’s partner in the project is Astra Senaka, an Anglo-Swedish pharmaceutical company.

     It’s time for the Serum Institute researchers to come up with the idea of a fast-paced vaccine to stave off Covid.  Serum and Oxford have previously been linked to a new drug being developed against malaria.  Serum, the horse of the vaccine industry, is thus involved in the production of Covshield.

     Serum replacement was Rs 3000 crore

     Oxford first tested it on monkeys, which are very close to the human genome.  The experiment then progressed to 1077 people in the UK.  The Serum Institute has set aside Rs 3,000 crore for this.  Had the vaccine trial failed, at least Rs 1500 crore would have been wasted.

     Serum is in the process of developing five vaccines in collaboration with various researchers.  There are many types of vaccines, including virus – based, protein based, viral vector based, and nucleic acid based.  Along with the Serum Institute, Bharat Biotech, Sydus Cadilla, Dr.  Indian pharmaceutical companies such as Reddy’s Lab, Biological E, Indian Immunologicals, Aurobindo Pharma, Genoa Bio Pharmaceuticals, Reliance Life Sciences, Hester Biosciences and Minwax are also active in the research.  In this, Sydas and Bharat Biotech are aiming for India’s own vaccine.

     Vaccine variety;  Capacity 130 crore

     The established production capacity of the Serum Institute is 130 crore chil (VIL) per year, including for measles, tetanus and polio.  At the manufacturing facility at Hadapsar, Pune, the virus-laden secretions are handled by robots.  This is to prevent infection by avoiding human contact.

     The vaccine, which flows through a rapid tube, fills up to 500 vials per minute and exits.  Eye-catching camera eyes make sure there is not a speck of dust in the bottles that swim into the packaging.

     The measles vaccine has been around for 34 years

     It took 34 years to develop a chickenpox vaccine.  It takes 15 years for cervical cancer and 4, 9 and 7 years to get vaccinated against measles (mumps,) measles and polio, respectively.  It took Covid vaccine just 9 months to reach the public from the laboratory.  Covid shattered the notion that it would take an average of 10 years to develop a new vaccine.

     Experts say that despite the US and UK spending billions of dollars encouraging pharmaceutical companies, various private pharma companies in India have reaped the benefits without significant government funding.

     India: Third World Vaccine Power

     The World Health Organization, UNICEF and organizations such as the Vaccine Alliance hope that India will become the world’s largest vaccine factory (25 per cent) after China, producing the world’s largest vaccine.

     About half of the world’s countries are waiting for the Indian vaccine

     There are 12 vaccines against Covid in the world market.  Of these, 3 are owned by India.  It is also an opportunity for India to integrate research excellence into the global arena.  The bottle also opens the Geo-Pharma Drug Diplomacy as a wing of friendship, humanity and healing among the nations of the world.

     The GAVI Global Vaccine Alliance, founded by the Bill Gates Foundation, is providing vaccine for measles, which is widespread among children in Karachi, through the Indian company Bharat Biotech.  This is because the vaccine is produced in the world only in India.  The Atmanirbhar Bharat that the Prime Minister says is thus coming true.  It should come as no surprise that India will become a medical gem in the region by providing the required Covid vaccine to Bangladesh and other neighboring countries.  If this leads to peace, the country will have the status of the world’s pharmacy.  Before Covid, India exported two-thirds of the vaccine produced here.

     Coming up, a one-time nasal spray

     The World Health Organization expects the Covid vaccine dose to be around 400 million this year alone.  Bharat Biotech claims that the single-dose vaccine will be released in June.  Sydes cadillac is a company that is preparing to modify the vaccine currently used against measles (measles).  More than 300 Covid vaccines are being tested in various parts of the world, taking part in the most extensive drug research in human history.  It is estimated that three-quarters of vaccines that pass the third stage are successful.

     Nine months of dedicated research, world-class technology, manufacturing-research partnership, investment, ministry support and the approval of the Drug Controller of India, the Department of Biotechnology and the ICMR have helped Indian pharmaceuticals to take the lead in this battle.  The Central Drugs Laboratory in Kasauli was also very supportive.  Although the research area was freed from lockdown, many raw materials were organized with great difficulty.

     Priya Abraham and her team, who took over as head of the National Institute of Virology in Pune, discovered 11 types of Covid genetic variants that shed light on the research.

     Third world allergies of multinational companies

     None of the world’s major multinational pharmaceutical companies is trying to find a vaccine for the pandemic that is spreading in third world tropical countries.  They did not take Covid seriously at first.  They are not interested in doing research on such fevers.  The reason is that it is a large non-profit sector.  Although influenza vaccines are produced for the cold countries, such multinationals are excluded from free immunization programs designed by the World Health Organization and others for the poor.  India, which deals with humanity in such situations, is in fact the drugstore of Asian-African countries.

     Various Vaccines: Production Capacity of India

     BCG (Bacillus comet Gurin) 1836 million dose

      DPT (Diphtheria petosis tetanus) 634 lakh dose

      TT (tetanus toxoid) 3787 lakh dose

     OPV (oral polio vaccine) 7778 lakh dose

     Measles – 1550 lakh dose

     TD (Tetanus Diphtheria) – 1200 lakh dose

     Hepatitis B – 860 lakh dose

     MMR (Measles Mumps and Rubella) – 513 million dose

     Pentavalent – 2565 lakh dose

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